The James Webb Space Telescope (JWST) is a space observatory with four science instruments operating from the visible to the mid-infrared projected to launch in 2018. It is designed to address four scientific themes (First Light and Reionization, The Assembly of Galaxies, The Birth of Stars and Protoplanetary Systems, and Planetary Systems and the Origin of Life), but its capabilities will enable an even broader spectrum of research. JWST is a international collaboration between NASA, ESA and CSA and will be operated by the JWST Science and Operations Center at the Space Telescope Science Institute in Baltimore, USA. Following the scheme of HST operations, instrument scientists involved in support JWST science operations will carry out several different tasks. The complexity and versatility of the 4 on-board instruments demand a high degree of coordination across several activities, such as the on-sky calibration observations or the software development for data quality analysis, or data reduction. Moreover, using their expertise on the instruments' capabilities, they will play a key role in helping JWST users design ambitious observing strategies and be successful in their scientific experiments. We will review the overall science operation plan for JWST from a Instrument Scientist perspective and will describe the role of ESA during the JWST science operation phase.