The JUICE spacecraft was launched on 14 April 2023 by Ariane 5 and will use Venus and Earth gravity assists in its 8.3 years cruise to Jupiter. After the Jupiter orbit insertion planned on 20th July 2031, the spacecraft will perform a 3.5 year tour in the Jovian system focusing on continuous observations of Jupiter's atmosphere and magnetosphere. During the tour, gravity assists with Callisto and Ganymede will shape the trajectory. Two targeted Europa flybys are included focusing on composition of the non water-ice material and active regions. Callisto gravity assists will be also used to raise the orbit inclination to 35° to enable observations of the Jupiter polar regions. The frequent Callisto flybys will enable unique remote observations of the moon and in situ measurements in its vicinity. The mission will culminate in a dedicated 11 months orbital tour around Ganymede during which the spacecraft will perform detailed investigation of the moon and its environment at different altitudes. The spacecraft will eventually impact on Ganymede.

The total mission duration is close to 12 years, of which about 4 years would be spent in the Jupiter system.